Blood Biomarkers as a Diagnostic Tool for Obstructive Sleep Apnea

The Dove Medical Press journal Nature and Science of Sleep has published a study that highlights the potential use of blood biomarkers as a diagnostic tool for obstructive sleep apnea. The article entitled Use of blood biomarkers to screen for obstructive sleep apnea demonstrates positive clinical trial results that suggest blood tests may be a useful screening tool and potentially superior to current diagnostic methods.

The study, which used male participants, found that concurrent elevations of hemoglobin A1c (HbA1c), C-reactive protein (CRP), and erythropoietin (EPO) indicated that a patient may have obstructive sleep apnea. The study demonstrated that blood biomarkers proved superior to the Epworth Sleepiness Scale (ESS) and other standard screening methods currently used for diagnosis, particularly in non-obese males. These tests were shown to correlate with disease severity and may assist in triaging patients for diagnosis and treatment.

In a statement, the authors said that they anticipated that use of objective blood tests will improve screening accuracy and timely diagnosis, improve patient management, decrease the incidence of diabetes and cardiovascular disease, and decrease healthcare costs.

Steven Shea, PhD, Nature and Science of Sleep editor-in-chief and founder of one of the first clinical sleep laboratories in the United Kingdom, says, “Diagnosis for sleep apnea usually requires expensive overnight polysomnography. An accurate, simple, quick, and cheap screening test would be ideal. Signs of sleep apnea detected from a blood sample is an important step in that direction and is particularly

Visit A Sleep Disorder Center For A Good Night’s Sleep

Sleeping is not just a luxury but a necessity in our lives. We need it in order to function normally and live healthily throughout all the days of our lives. Our sleeping requirement varies as we age. Babies do nothing but just sleep almost the entire day but the length of their sleep reduces as they grow up. Kids still have the biggest requirement because of the rapid growth and development they go through and it is evident in their growing bodies. Once you enter adulthood, sleep becomes more of a luxury because of heavier workload and more responsibilities you have to juggle day in and day out. Yet even if you can claim that your body has reached maturity once you hit adulthood, it does not mean you need less sleep than your younger counterparts.

Sleep is essential for everyone no matter what your age is. Adults need it too because they do so much more now they need the energy to help them last throughout the day and night. They can’t just reason out that they lack sleep as an excuse to skip school or miss work because they should know better that their bodies need to rest too or else they succumb to sickness. It’s the reason why sleep clinics are on the rise these days. Many people finally admit that they lack sleep for a lot of reasons but it should not stop them from getting …

Can Tech Save Us From Being Sleep Zombies?

When we hear the word technology, we immediately think of its negative effects on our health including our sleep. It is easy to get lost for hours on end when we are engaged on our tech gadgets, whether it is a handy smartphone, a multifunctional laptop or PC, or an equally addictive game such as Xbox or PlayStation. However, has it ever occurred to you that you can use technology to your advantage? It might seem incredulous to you especially if you have only seen the dark side of technology that has enslaved the human race but there are actually good technologies that help promote good health and uphold normal and healthy living for one and all.

Have you heard of sleep technology? Well, it simply means the way it is, a technology used to enhance sleep and promote sleep health. They range from small high-tech devices like smartwatches and fitness trackers that monitor and regulate sleep to amazing bed and pillow technologies that can transform the entire sleeping experience. It is high time we do our body good and limit our exposure to dangerous blue light by supporting technologies that help us enjoy sleeping once more and enable us a higher awareness of ourselves so we don’t just easily fall prey to more common tech distractions that are so widespread right now.

Technology is bad for sleep. It keeps us constantly exposed to an endless cycle of bad

How to Improve Adherence in Patients Titrated at Home by Auto CPAP [On-demand Webinar]

Sleep Review‘s webinar How to Improve Adherence in Patients Titrated at Home by Auto CPAP is now available for free and immediate on-demand viewing.

More people are being diagnosed with obstructive sleep apnea and starting positive airway pressure therapy without ever spending the night inside a sleep disorders center. Sleep clinicians are challenged with ensuring that patients who are titrated at home via auto CPAP (also known as APAP) start and stick to their treatment. Learn real-world approaches to improving adherence in patients titrated at home by auto CPAP from physicians with expertise in prescribing the devices.

In this free 1 hour, 22-minute webinar hosted and moderated by Sleep Review, attendees will learn:

  • what the research says about in-lab versus at-home titration adherence outcomes
  • how to select patients who can undergo at-home titration and tips for interfacing with payors for patients that need in-lab titrations
  • specific tips for education and follow-up to boost adherence in patients titrated at-home.

The on-demand version includes a recording of the live Q&A segment.


Dennis Auckley, MD

Dennis Auckley, MD

Dennis Auckley, MD
Center for Sleep Medicine at MetroHealth Medical Center; Case Western Reserve University, Cleveland, Ohio

Dennis Auckley, MD, is director of the Center for Sleep Medicine at MetroHealth Medical Center in Cleveland, Ohio, and professor of medicine at Case Western Reserve University. He is board certified in sleep medicine, pulmonary disease, and critical care medicine.

Dr. Auckley directs the Center for Sleep Medicine

When to Prescribe Advanced PAP Therapies for Patients Struggling with CPAP [On-demand Webinar]

Sleep Review‘s webinar When to Prescribe Advanced PAP Therapies for Patients Struggling with CPAP is now available for free and immediate on-demand viewing.

When obstructive sleep apnea patients fail or can’t adhere to the continuous form of positive airway pressure therapy (commonly known as CPAP), there are other options that clinicians should explore to get patients to adherence. In some cases, these other options include advanced positive airway pressure modes such as bilevel devices and adaptive servo-ventilation (ASV), which take into account such parameters as expiratory pressure intolerance. Learn what the literature says about these “rescue” devices as well as real-world approaches to switching patients to advanced therapies when indicated.

In this free 1 hour, 22-minute webinar hosted and moderated by Sleep Review, attendees will learn:

  • what the research says about compliance on CPAP versus auto-bilevel PAP and ASV in specific patient populations;
  • practical advice for when and how to switch sleep apnea patients to more advanced therapy modes;
  • the data signatures of high risk apnea phenotypes and the clinical data on use of therapies targeting high loop gain and sleep fragmentation, as adjunct to positive airway pressure therapies.

The on-demand version includes a recording of the live Q&A segment.


Mark J. Muehlbach, PhD, DABSM

Mark J. Muehlbach, PhD, DABSM

Mark J. Muehlbach, PhD, DABSM
Clayton Sleep Institute, St. Louis, MO

Mark Muehlbach, PhD, DABSM, is the clinical director of the Sleep Centers at Clayton Sleep Institute. He earned his doctoral degree

Maxillomandibular Advancement Surgery Successful Treatment Option for OSA

A SLEEP 2018 poster presentation examined what variables predict success for this alternative for patients who fail CPAP.

For patients who fail to adhere to CPAP therapy, maxillomandibular advancement surgery has a success rate of 89% for moderate to severe obstructive sleep apnea (OSA) patients, according to a study presented as a poster at SLEEP 2018. The research abstract, published in the journal Sleep, also evaluated radiographic and clinical treatment variables that may predict the surgery’s success.

“We thought about different ways of what we could find for predictors of success for addressing obstructive sleep apnea,” says Daniel Taub, DMD, MD, an author of the study. “And so we just compiled some data looking at the success rate of what we had and tried to figure out what variables are used to predict success.”

The study was a retrospective analysis looking at patient data and doing some radiographic calculations to see what variables they could find in the successful population compared to the failures. It found that patients in whom the surgery was successful had shorter cephalometrically established Pogonion-CE and cross section airway than other patients. Body mass index, posterior airway space changes, and minimum oxygen saturation levels were not linked with predicting surgery success.

There is a large population that fails CPAP therapy and aren’t candidates for other treatment options, Taub says. “So, this is sort of a last resort where you’re doing a surgical

Transition from CPAP to BiPAP Reduces Aerophagia Symptoms

The SLEEP 2018 abstract poster presentation also examined whether the switch from CPAP to bilevel PAP therapy would improve therapy adherence in patients experiencing aerophagia.

Adherence to CPAP has proven itself to be an ongoing battle for many obstructive sleep apnea (OSA) patients. One issue that continues to present itself, according to a recent abstract presented as a poster at SLEEP, is aerophagia, or “swallowing air.” The research abstract was published recently in an online supplement of the journal Sleep.

“I had seen a few patients afflicted by the same symptoms of aerophagia, so [this study] came out of my own clinical experience,” says Kathy Tran, DO, an author of the study.

Tran and her research partner examined charts of patients who had undergone bilevel PAP (BiPAP) therapy, and who had been previously using CPAP with presented complaints of aerophagia such as belching and bloating. Of the 14 qualified patients who had transitioned from CPAP to BiPAP, 10 of them (71.4%) experienced a resolution of aerophagia.

“This study tells you that if you screen patients for symptoms of aerophagia, you can essentially eliminate that as a cause for them not using their PAP therapy,” says Tran. “So, if you switch them from CPAP to BiPAP you can increase the likelihood that they’ll use it.”

Although a majority of patients found relief from the symptoms, there was no significant improvement in therapy compliance as the researchers hoped

Increased Age, Reduced BMI Are Predictors of Upper Airway Stimulation Therapy Success

A SLEEP poster presentation looked at demographic predictors to determine success of Inspire UAS success in patients with obstructive sleep apnea.

A new study finds that increased age and a reduced body mass index (BMI) are predictors of response in obstructive sleep apnea (OSA) patients undergoing upper airway stimulation (UAS). The poster was presented at SLEEP 2018 and the abstract was published recentlyin an online supplement of the journal Sleep. It was supported by Inspire Medical Systems Inc, makers of the Inspire UAS, the only FDA cleared neurostimulation device for OSA available in the United States to date. The researchers selected patients who had an implanted UAS system—for CPAP intolerant patients with moderate to severe OSA—and followed up at 6 and 12 months post-implant.

“We were trying to collect data on a large set of patients undergoing UAS and potentially see which factors predict good outcome,” says Richard Schwab, MD, an author of the study. “We found that both increased age and a reduced BMI helped patients do better.” Overall, 80% of patients in the study were deemed UAS successes.

The research team also looked at baseline apnea-hypopnea index (AHI) but found it wasn’t a significant predictor.

While more research would need to be done to tell whether age and BMI are the main predictors of UAS therapy success, Schwab says it’s important to note an underlying message. “It’s probably too early to just assume that

Parents want to sleep the teenage years

Wake me up when it’s all over!!! Ha! Life is a gift and nobody wants to change what they have, but it’s lucky we can deal with whatever is thrown at us because it can be tough. And just when you think it’s tough; there is another one! Different people handle different situations and most […]

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The Dangers Of Sleep Apnea Clinics

We may have achieved so much in terms of innovation and advancements but we are still clueless on how to completely eradicate many maladies that make life hard for all of us at one point or another. We have a lot of things going in that 24 hours each day is no longer enough for us to finish everything every single day. While we celebrate at the seeming non-existence of boredom anymore, there are things that pose a new threat, one that is far bigger and more deadly than getting bored of our wits for hours on end. Our addiction to technology has opened up a whole new world of possibilities and helped keep us entertained 24/7 but it has also deprived us of precious sleep. As a result, we get on with our days with only the minimum number of hours of sleep and it is seriously messing up with our health and well-being.

Chronic lack of sleep and several other sleep-related disorders and issues have prompted the popularity of sleep clinics. Of course, there is a demand for their services, a big one at that. People really have difficulty falling and staying asleep. And even if they do, it isn’t as fitful or as rejuvenating as it should be.

Now, with the demand for sleep clinics continuing to soar, some may take advantage of the situation and this where the problem begins. As of date, many Canadian …